High-Risk Individuals for Psychosis show Grey-Matter Abnormalities

Abnormalities in grey-matter (GM) were investigated in a group of clinically high-risk individuals for psychosis and healthy control subjects. Furthermore, the association among psychosocial functioning and neurocognition was also investigated (Zikidi et al., in press).

The authors found no alterations in GM across the cortices, however, in clinically high-risk participants changes in a subgroup of these participants were found in the frontal lobe in addition to an association with lower psychotic symptoms in the occipital lobe.

A small correlation was found with alterations in the intensity of grey matter and impairments in neurocognitive function (Zikidi et al. in press).